References

“SaferColon™ is a unique colon cleanser”
“The SAFER COLON formula uses natural herbs to help eliminate impacted waste from the colon, cleansing the colon gently while assisting in the proper absorption of vitamins and minerals.”

• “The concept of cleansing is actually a metaphorical explanation for a therapy that improves detoxification via the liver and gastrointestinal tract and reduces inflammation or irritation to mucous membranes of the GI tract.” Horne S. Colon cleansing: a popular, but misunderstood natural therapy. J Herb Pharmacother. 2006;6(2):93-100.
• “A Tibetan preparation of twelve different plant extracts, commonly referred to and marketed as Padma Lax, was tested in IBS-C patients over the course of three months in a randomized and double-blinded observational study and showed significant improvements over a placebo in reducing constipation, abdominal pain, and flatulence. The dose had to be adjusted for some of the patients since they developed loose stools that bordered on diarrhea indicating that this combination herbal product may have significant potential as a laxative. The ingredient list includes the known laxatives rhubarb root, cascara bark, and nux vomica seeds, which have been used as strong laxatives in severe constipation in traditional medicines across the world”. Grundman O, Saunjoo LY. Complimentary and alternative medicines in irritable bowel syndrome: An integrative view.World J Gastroenterol. Jan 14, 2014; 20(2): 346-362.
• “Fennel is used as a laxative in the treatment of mild digestive disorders due to its gastrointestinal effects, namely stimulation of motility and, at higher concentrations, antispasmodic action. Administration of fennel seed oil emulsion has been shown to be superior to placebo in reducing the intensity of infantile colic in a randomized trial”. “Senna is a potent laxative, and its use in patients with chronic constipation has been assessed. “This is the first randomized controlled trial to demonstrate the safety and laxative efficacy of a phytotherapic tea containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia”. Picon PD, Picon RV, Costa AF, Guilherme BS, Amaral KM, Aboy AL, Henriques AT. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifoliafor chronic constipation. BMC Complementary and Alternative Medicine 2010, 10:17.

Weight Loss Claims/ Reduce Belly Fat Claims

“Flush Pounds Naturally”
“Lose body weight”
“Remove Stubborn belly fat”
“A colon cleansing can result in an efficient weight loss and a flatter more toned belly.”

• “In obese individuals with prediabetes or early untreated DM, Aloe QDM complex reduced body weight, BFM, and insulin resistance”. Chol HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metqbolic effects of aloe vera gel complex in obese prediabetics and early non- treated diabetic patients: randomized controlled trial. Nutrition. 2013 Sep;29(9):1110-4.

Detoxification Claims

“Detoxify Fast and Safe…”
“Colon detoxification helps with better blood flow more restful sleep and a boost in energy.”
“Countless people use SAFER COLON every day as an all natural method to gently flush away unwanted toxins from the colon.”
“Flush harmful waste”

• “Most literature on detoxification refers to liver enzymes, as the liver is the site of the majority of detoxification activity for both endogenous and exogenous compounds. However, the first contact the body makes with the majority of xenobiotics is the gastrointestinal tract. Over the course of a life- time, the gastrointestinal tract processes more than 25 tons of food, which represents the largest load of antigens and xenobiotics confronting the human body.” “Adequate first pass metabolism of xenobiotics by the gastrointestinal tract requires integrity of the gut mucosa. Compromised barrier function of the mucosa will easily allow xenobiotics to transit into the circulation without opportunity for detoxification. Therefore, support for healthy gut mucosa is instrumental in decreasing toxic load.” Liska DAJ. The Detoxification Enzyme Systems. Alt Med Review. Volume 3, Number 3; 1998.
• 2. “Data from other populations of the world show average stool weight to vary from 72 to 470 g/day and to be inversely related to colon cancer risk (r = -0.78).” Cummings JH, Bingham SA, Heaton KW, Eastwood MA. Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology. 1992 Dec;103(6):1783-9.

Mood Improvement Claims

“Happier and better moods”

• Mucosal SERT and tryptophan hydroxylase-1 expression are decreased in experimental inflammation, IBS-C, IBS-D, and ulcerative colitis.” Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol. 2005 May-Jun;39(5 Suppl 3):S184-93.

Other Claims…

“Flatulence, gas & bloating Impaired digestion”

• “The use of peppermint extracts has been studied in a number of clinical trials which evaluated the administration of enteric- coated peppermint oil capsules to IBS patients. The duration of the trials ranged from 4-8 wk and was not divided into specific IBS subtypes. The trials showed a significant reduction in abdominal pain and severity compared to placebo after 4 wk.” Grundman O, Saunjoo LY. Complimentary and alternative medicines in irritable bowel syndrome: An integrative view.World J Gastroenterol. Jan 14, 2014; 20(2): 346-362. “It's NOT uncommon for people to carry as much as thirty pounds of toxic waste in their colon. In fact, some bowels, when autopsied, weighed up to 40 pounds with a diameter of 12" (30cms) with only a narrow passage through which feces could be eliminated.”
• “Balloon Man” colon remains are located in the Mutter Museum in Philidelphia, Pennsylvania, which contained over 40 pounds of fecal material when removed from the man’s body. http://en.wikipedia.org/wiki/Mutter_Museum “Colons that contain parasites are often impacted with mucous that prevents nutrients for cells from being absorbed. As a result you tend to eat more and more in order to get enough nutrition to get through the day which, in turn, leads to more weight gain.”
• “Beidellitic montmorillonite is a natural clay, consisting of a double aluminium and magnesium silicate. Because of its leaf-like structure and its plastic viscosity, it has coating properties associated with the ability of gas absorption and a protective quality for the gastrointestinal mucosa.” Ducrotte P, Dapoigny M, Bonzai B, Siproudhis L. Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial. Aliment Pharmacol. Ther 2005;21:435-444. “But you can STOP the cycle. SaferColon™ is a unique colon cleanser. It contains natural ingredients that help flush harmful food debris and toxins from the colon leaving it clean, disinfected, and functioning properly.”*
• “The driving force behind the therapeutic use of bentonite (TERMINOLOGY BOX) for digestive and gastrointestinal maladies that cause borborygmi— the stomach rumblings caused by gas moving through the intestines—is the attractive power of clay-particle surfaces (Carretero et al. 2006). Negatively charged surfaces attract positively charged substances, and like a sponge, some clay minerals absorb substances between the layers of their crystal structure. Cation exchange can take up or release toxins or nutrients (e.g. Ca, Fe) that may be used by bacteria.” Williams LB, Haydel SE, Ferrel RE Jr. Bentonite, Bandaids, and Borborygmi. Elements (Que). 2009 April 1;5(2):99-104.
• “Moreover, earlier studies have shown conclusively that NS reduces the bioavailability of AF and the findings from this study suggest that NS clay also reduces the bioavailability FB1” Robinson A, Johnson NM, Phillips TD. Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B1 exposure in rats and humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012; 29(5): 809–818. “The standard American Diet (or SAD) for most Americans consists of ultra-high level fat content foods with high levels of preservatives. Add to that pollution from red and white meats, water, air and other environmental factors can leave your insides feeling yucky and run-down.”
• “In particular, nutritional patterns collectively termed the " ", including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and 'fast foods', promote obesity, metabolic syndrome, and cardiovascular disease”. Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of “Western diet” in inflammatory autoimmune diseases. Curr Allergy Asthma Rep. 2014 Jan;14(1):404. “Almost Everyone Has Parasites & Your intestines provide the perfect breeding ground for parasites.” “Ninety percent of humans will have a problem with parasites in their lifetime. Parasites are not just something that other people get – a malady reserved for citizens of developing countries. Everywhere we go, during just about everything we do, people are vulnerable to parasitic infestation. The World Health Organization (WHO) classifies parasites as among the six most dangerous health problems that infect humans. Parasites enjoy making their homes nestled within impacted waste as well as in the linings of colon walls. Living inside our intestines, these microorganisms gain the upper hand by virtue of their sheer numbers – both in kind and in population. They thrive because of the unique ways in which they have adapted their life cycles in order to ensure the perpetuation of their species within their unsuspecting hosts: us.”
• “Parasitic infections, caused by intestinal helminths and protozoan parasites, are among the most prevalent infections in humans in developing countries. In developed countries, protozoan parasites more commonly cause gastrointestinal infections compared to helminths. Intestinal parasites cause a significant morbidity and mortality in endemic countries.” Haque R. Human Intestinal Parasites. J Health Popul Nutr. 2007 Dec:25(4)387-391.